The college was formally inaugurated on the 29 December 1952 by His Eminence Norman Thomas Cardinal Gilroy, Papal Legate to India. Fatima was subsequently elevated to the status of a first grade college with the introduction of degree courses in Commerce, Economics and Zoology. This was followed by introduction of various courses

1961 : Postgraduate courses in Botany and Commerce.

1964 : Postgraduate courses in Physics and Zoology.

1965 : Postgraduate courses in Economics and English.

1966 – 67 : A modern open-access library, an auditorium named Bishop Jerome Hall.

1980 : St Joseph’s Guidance and Counselling Centre.

1981 : Degree course in Psychology.

1984 : Centre for Research and Postgraduate Studies Block.

1988 : Upgradation of the Dept of Zoology as Research Centre

1993 : Degree course in Polymer Chemistry, the first in the University of Kerala.

1995 : Postgraduate course in Chemistry.

1997 – 98 : Computer labs in Departments of Mathematics and Commerce.

1998 : Postgraduate course in Malayalam.

1999 : Postgraduate course in Mathematics.
: Upgradation of the Dept of commerce as a Research Centre.
: Language Laboratory for the department of English.
: Renovation of the Hockey stadium.

2000 : Golden Jubilee celebrations.

2001 : Accreditation by NAAC at Four Star level.

2001–02 : UGC-aided B.Sc BioTechnology.
: B.Sc. in Computer Science.
: B.Com. in Computer Applications and BCA under IDE.

2004 : M.Sc. in Computer Science (IDE)
: Computer networking of the College Office Library and the various Departments initiated under the MPLAD Scheme of Shri N. K. Premachandran M.P. (former student) & Shri P. Rajendran, M.P.

2006 : Upgradation of the Departments of Economics and English to Research Centres.
: UGC-aided career-oriented courses.

2007 : NAAC Reaccreditation (B ++ Level).

2010 : FIST assistance for Departments of Zoology, Botany and Chemistry.
: UGC-aided NET / SET coaching programmes.
: UGC-aided coaching classes for entry in services.
: UGC Network Resources.

2011 : Skill Enhancement Comupter Training and Resource Centre for Women.2012 : Diamond Jubilee year of the college.

2012 : UGC-Aided new course (M.Sc. Food and Dairy Biotechnology).

2013 : NAAC reaccredited with “A” Grade.
: M.Sc in Psychology.
: Departments of Physics & Chemistry elevated to the status of Research Centres.

2014 : Conferred Autonomous status.
: BA in History.

2015 : Golden Jubilee Block and College Chapel.
: Upgradation of the Dept of Botany as Research Centre.
: B.A. in English Language Literature & Communication (Self-Financing)
: B.Com in Cooperation (Self-Financing)
: B.Sc in Computer Science (Self-Financing)

2016 : B.Com. in Computer Application (Self-Financing)
: BCA (Self-Financing)
: New Block for Department of History

2017 : Bishop Feridand Maria Ossi Block
: Renovation of the Centre for Research & PG Studies Block
: Launching of Fatima Civil Service Academy.
: Launching of Fatima School of Foreign Language.
: Silver Zone in IAB Blind Empowerment Champions

2019 : Ranked 83 by NIRF.
: Bishop Catalani Campus.

2020 : NAAC Re-Accredited A Grade.
: Set up IQAC Board Room.

2021 : KSCSTE SARD Support.
: BSc in Geology.