The college was formally inaugurated on the 29 December 1952 by His Eminence Norman Thomas Cardinal Gilroy, Papal Legate to India. Fatima was subsequently elevated to the status of a first grade college with the introduction of degree courses in Commerce, Economics and Zoology. This was followed by introduction of various courses

1961          : Postgraduate courses in Botany and Commerce.

1964         : Postgraduate courses in Physics and Zoology.

1965         : Postgraduate courses in Economics and English.

1966 – 67 : A modern open-access library, an auditorium named Bishop Jerome Hall.

1980         : St Joseph’s Guidance and Counselling Centre.

1981          : Degree course in Psychology.

1984         : Centre for Research and Postgraduate Studies Block.

1988         : Upgradation of the Dept of Zoology as Research Centre

1993         : Degree course in Polymer Chemistry, the first in the University of Kerala.

1995         : Postgraduate course in Chemistry.

1997 – 98 : Computer labs in Departments of Mathematics and Commerce.

1998         : Postgraduate course in Malayalam.

1999         : Postgraduate course in Mathematics.
                 : Upgradation of the Dept of commerce as a Research Centre.
                 : Language Laboratory for the department of English.
                 : Renovation of the Hockey stadium.

2000        : Golden Jubilee celebrations.

2001         : Accreditation by NAAC at Four Star level.

2001–02  : UGC-aided B.Sc BioTechnology.
                 : B.Sc. in  Computer Science.
                 : B.Com. in Computer Applications and BCA under IDE.

2004        : M.Sc. in Computer Science (IDE)
              : Computer networking of the College Office Library and the various Departments initiated under the MPLAD Scheme of Shri N. K. Premachandran M.P. (former student) & Shri P. Rajendran, M.P.

2006        : Upgradation of the Departments of Economics and English to Research Centres.
                 : UGC-aided career-oriented courses.

2007        : NAAC Reaccreditation (B ++ Level).

2010        : FIST assistance for Departments of Zoology, Botany and Chemistry.
                 : UGC-aided NET / SET coaching programmes.
                 : UGC-aided coaching classes for entry in services.
                 : UGC Network Resources.

2011      : Skill Enhancement Comupter Training and Resource Centre for Women.2012 : Diamond Jubilee year of the college.

2012         : UGC-Aided new course (M.Sc. Food and Dairy Biotechnology).

2013         : NAAC reaccredited with “A” Grade.
                 : M.Sc in Psychology.
                 : Departments of Physics & Chemistry elevated to the status of Research Centres.

2014         : Conferred Autonomous status.
                 : BA in History.

2015         : Golden Jubilee Block and College Chapel.
                 : Upgradation of the Dept of Botany as Research Centre.
                 : B.A. in English Language Literature & Communication (Self-Financing)
                 : B.Com in Cooperation (Self-Financing)
                 : B.Sc in Computer Science (Self-Financing)

2016         : B.Com. in Computer Application (Self-Financing)
                 : BCA (Self-Financing)
                 : New Block for Department of History

2017         : Bishop Feridand Maria Ossi Block
                 : Renovation of the Centre for Research & PG Studies Block
                 : Launching of Fatima Civil Service Academy.
                 : Launching of Fatima School of Foreign Language.
                 : Silver Zone in IAB Blind Empowerment Champions

2019         : Ranked 83 by NIRF.
                 : Bishop Catalani Campus.